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Article

Characterization of the structural determinants of the ubiquitin-dependent proteasomal degradation of human hepatic tryptophan 2,3-dioxygenase.

The Biochemical journal - 28 May 2021

Liu Yi, Kim Sung-Mi, Wang YongQiang, Karkashon Shay, Lewis-Ballester Ariel, Yeh Syun-Ru, Correia Maria Almira

Abstract excerpt

Human hepatic tryptophan 2,3-dioxygenase (hTDO) is a homotetrameric hemoprotein. It is one of the most rapidly degraded liver proteins with a half-life (t1/2) of ∼2.3 h, relative to an average t1/2 of ∼2-3 days for total liver protein. The molecular mechanism underlying the poor longevity of hTDO remains elusive. Previously, we showed that hTDO could be recognized and ubiquitinated by two E3 ubiquitin (Ub)...

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PMID: 33960368
DOI: 10.1042/BCJ20210213
PMCID: PMC8892992

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