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Article

Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase.

The Journal of biological chemistry - 8 Aug 2003

Littlejohn Tamantha K, Takikawa Osamu, Truscott Roger J W, Walker Mark J

Abstract excerpt

L-Tryptophan is the least abundant essential amino acid in humans. Indoleamine 2,3-dioxgyenase (IDO) is a cytosolic heme protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the first and rate-limiting step in the major pathway of tryptophan metabolism, the kynurenine pathway. The physiological role of IDO is not fully understood but is of great interest, because IDO is widely...

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PMID: 12766158
DOI: 10.1074/jbc.M301700200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase.PMID 12766158Read ↗

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