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Article

Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase.

The Biochemical journal - 15 Feb 2006

Peña Maria Marjorette O, Xing Yang Yang, Koli Sangita, Berger Franklin G

Abstract excerpt

Thymidylate synthase (TS) catalyses the reductive methylation of dUMP to form dTMP, a reaction that is essential for maintenance of nucleotide pools during cell growth. Because the enzyme is indispensable for DNA replication in actively dividing cells, it is an important target for cytotoxic drugs used in cancer chemotherapy, including fluoropyrimidines (e.g. 5-fluorouracil and 5-fluoro-2'-deoxyuridine) and...

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Identifiers

PMID: 16259621
DOI: 10.1042/BJ20051479
PMCID: PMC1386034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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