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Article

Characterization of the bipartite degron that regulates ubiquitin-independent degradation of thymidylate synthase.

Bioscience reports - 18 Jan 2013

Barbour Karen W, Xing Yang-Yang, Peña Edsel A, Berger Franklin G

Abstract excerpt

TS (thymidylate synthase) is a key enzyme in the de novo biosynthesis of dTMP, and is indispensable for DNA replication. Previous studies have shown that intracellular degradation of the human enzyme [hTS (human thymidylate synthase)] is mediated by the 26S proteasome, and occurs in a ubiquitin-i...

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Identifiers

PMID: 23181752
DOI: 10.1042/BSR20120112
PMCID: PMC3549573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23181752-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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