Article

Generating and navigating single cell dynamics via a geodesic bridge between nonlinear transcriptional and linear latent manifolds

2026-07-21

Abstract excerpt

<title>Abstract</title> <p>Time-series single-cell RNA sequencing (scRNA-seq) captures cellular processes as sparse and unpaired snapshots, limiting our ability not only to reconstruct continuous cell state transitions, but also to navigate between states in a controlled and interpretable manner. Here we present GeoBridge, a framework that formulates biological-time interpolation as a Riemannian metric-learning p...

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Literature Corpus work: 12e86626-e7c6-5be0-9cb9-5104c8354ec1
DOI: 10.21203/rs.3.rs-8917927/v1

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