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SPARC: A Graph-based Optimization Framework for Directional Trajectory Reconstruction Across Ordered Single-Cell Conditions

2026-07-11

Abstract excerpt

Single-cell transcriptomics has enabled systematic profiling of cellular states across ordered biological contexts, including developmental stages, treatment phases, disease progression, and anatomical compartments. A central challenge is to reconstruct trajectories that respect the directionality imposed by biology or experimental design. Existing trajectory inference methods reconstruct cell-state progressions f...

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Literature Corpus work
6f921602-aff5-50e7-8455-6fb80fcff5d6
DOI
10.64898/2026.07.07.736532
Open publication

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SPARC: A Graph-based Optimization Framework for Directional Trajectory Reconstruction Across Ordered Single-Cell ConditionsDOI 10.64898/2026.07.07.736532
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