Article

PROFET Predicts Continuous Gene Expression Dynamics from scRNA-seq Data to Elucidate Heterogeneity of Cancer Treatment Responses

2025-07-03

Abstract excerpt

Single-cell RNA sequencing profiles cellular heterogeneity but captures only static snapshots, limiting inference of gene expression dynamics. We developed PROFET (Particle-based Reconstruction Of generative Force-matched Expression Trajectories), a framework that reconstructs continuous, nonlinear single-cell trajectories from sparsely sampled scRNA-seq time series. PROFET combines a particle-based gradient-flow...

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Literature Corpus work: 340fc23e-3212-59a3-a672-be05ec5bf7eb
DOI: 10.1101/2025.06.27.662030

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