Article

Identifying Novel Therapeutic Targets for Overcoming TNBC Chemo Resistance Through Comprehensive CRISPR-Cas9 Genome Screening

2024-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Triple-negative breast cancer (TNBC) represents 15-20% of cases but disproportionately contributes to 35% of breast cancer deaths. Chemotherapy resistance remains a significant challenge in TNBC treatment. In this study, we identified the MDA-MB-231 cell line as the most representative model for TNBC chemotherapy-poor responders by comparing genomic profiles from TNBC cell lines and patient samp...

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Literature Corpus work: 4474510f-01cf-5d0b-a134-34eeda64414f
DOI: 10.1101/2024.05.14.594192

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