Article
PPLine: An Automated Pipeline for SNP, SAP, and Splice Variant Detection in the Context of Proteogenomics.
Journal of proteome research - 4 Sept 2015
Krasnov George Sergeevich, Dmitriev Alexey Alexandrovich, Kudryavtseva Anna Viktorovna, Shargunov Alexander Valerievich, Karpov Dmitry Sergeevich, Uroshlev Leonid Andreevich, Melnikova Natalya Vladimirovna, Blinov Vladimir Mikhailovich, Poverennaya Ekaterina Vladimirovna, Archakov Alexander Ivanovich, Lisitsa Andrey Valerievich, Ponomarenko Elena Alexandrovna
Abstract excerpt
The fundamental mission of the Chromosome-Centric Human Proteome Project (C-HPP) is the research of human proteome diversity, including rare variants. Liver tissues, HepG2 cells, and plasma were selected as one of the major objects for C-HPP studies. The proteogenomic approach, a recently introduced technique, is a powerful method for predicting and validating proteoforms coming from alternative splicing,...
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