Article

Naturally occurring ZCCHC3 variants modulate antiretroviral activity in cynomolgus macaques

2026-05-22

Abstract excerpt

Many mammalian cells restrict viral replication by utilizing various host restriction factors. We recently demonstrated that CCHC-type zinc-finger-containing protein 3 (ZCCHC3) suppresses human immunodeficiency virus type 1 (HIV-1) replication through multiple mechanisms. We also revealed that single-nucleotide polymorphisms (SNPs) in human ZCCHC3 affect its antiviral function; however, whether similar genetic and...

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Literature Corpus work: cfc7afe1-b331-5185-ade6-a2410d9f67fa
DOI: 10.64898/2026.05.21.726815

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