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Whole genome sequencing of SIV-infected macaques identifies candidate loci that may contribute to host control of virus replication

1 Nov 2014

Abstract excerpt

BACKGROUND: A small percentage of human immunodeficiency virus (HIV)-infected people and simian immunodeficiency virus (SIV)-infected macaques control virus replication without antiretroviral treatment. The major determinant of this control is host expression of certain major histocompatibility complex alleles. However, this association is incompletely penetrant, suggesting that additional loci modify the major...

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PMID: 25418588
DOI: 10.1186/s13059-014-0478-z

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