Article

The Impact of Methylglyoxal and SOD1 Mutation on TDP-43 Interaction in ALS Proteinopathy

2025-09-26

Abstract excerpt

<h4>Introduction</h4> Proteinopathy is a key feature of amyotrophic lateral sclerosis (ALS) that causes the loss of motor neurons. Glycated SOD1 increases the levels of phospho-TDP-43, a form that aggregates in the cytosol of neurons experiencing neurodegeneration in most ALS cases. <h4>Objective</h4> Here, we evaluated whether TDP-43 interacts with SOD1 and the impact of methylglyoxal (MGO) and G93A SOD1, found...

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Literature Corpus work: cfb0c807-a43a-50f3-85d1-0ae91847fb8b
DOI: 10.1101/2025.09.25.678586

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