Article
Molecular Modulation of the Crosstalk Between TDP-43 and SOD1.
International journal of molecular sciences - 10 Apr 2026
Ribeiro Gabriela D, Queiroz Daniela D, Monteiro-Neto José R, Gerhardt Ellen, de Souza Gabriel F, Albino Paola C S C, Paranhos Luan H, Outeiro Tiago F, Eleutherio Elis C A
Abstract excerpt
Glycation of superoxide dismutase 1 (SOD1) has been shown to modulate the cytosolic levels of phosphorylated TAR DNA-binding protein 43 (TDP-43), a hallmark of amyotrophic lateral sclerosis (ALS) pathology. In this study, we investigated the interaction between TDP-43 and SOD1 and assessed how methylglyoxal (MGO)-induced glycation and the ALS-associated G93A SOD1 mutation affect this interplay in H4 cells. MGO...
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