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Article

ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics.

Acta neuropathologica - 1 Oct 2016

Gal Jozsef, Kuang Lisha, Barnett Kelly R, Zhu Brian Z, Shissler Susannah C, Korotkov Konstantin V, Hayward Lawrence J, Kasarskis Edward J, Zhu Haining

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Mutations in Cu/Zn superoxide dismutase (SOD1) are responsible for approximately 20 % of the familial ALS cases. ALS-causing SOD1 mutants display a gain-of-toxicity phenotype, but the nature of this toxicity is still not fully understood. The Ras GTPase-activating protein-binding protein G3BP1 plays a critical role in stress granule...

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Source

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Identifiers

PMID: 27481264
DOI: 10.1007/s00401-016-1601-x
PMCID: PMC5023729

Genes

SOD1
TIA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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