Article

Excitotoxicity and genetics of amyotrophic lateral sclerosis: effects of intracellular calcium accumulation on proteins encoded by the major genes underlying the disease

2021-02-15

Abstract excerpt

<title>Abstract</title> <p>The aetiology of Amyotrophic Lateral Sclerosis (ALS), a fatal and incurable disease caused by motor neuron degeneration, is still poorly understood. The discovery of genetic forms of ALS helped to shed light on the mechanisms underlying this pathology, but also showed how complex these mechanisms are. Excitotoxicity is one of the processes strongly suspected to play a role in motor neur...

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Literature Corpus work: 219385f6-f8dc-54d7-b235-41f41577cf40
DOI: 10.21203/rs.3.rs-220372/v1

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