Article

Subtyping active-site inhibitor binding mode to Abl kinase using super-resolution nanopore tweezers.

2026-08-29

Abstract excerpt

Accurate determination of kinase inhibitor binding modes could provide essential information for understanding resistance mechanisms and accelerating drug discovery. While conventional structural methods such as X-ray crystallography, cryo-EM and NMR provide high-resolution information but are low-throughput and capture largely static snapshots of dynamic protein-ligand interactions Here, we introduce a single-mol...

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Literature Corpus work: cfa6f233-a260-5ba5-8be0-d8fee7baafb1
DOI: 10.64898/2026.08.27.747610

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