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Article

Conformational states dynamically populated by a kinase determine its function.

Science (New York, N.Y.) - 9 Oct 2020

Xie Tao, Saleh Tamjeed, Rossi Paolo, Kalodimos Charalampos G

Abstract excerpt

Protein kinases intrinsically sample a number of conformational states with distinct catalytic and binding activities. We used nuclear magnetic resonance spectroscopy to describe in atomic-level detail how Abl kinase interconverts between an active and two discrete inactive structures. Extensive differences in key structural elements between the conformational states give rise to multiple intrinsic regulatory...

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Identifiers

PMID: 33004676
DOI: 10.1126/science.abc2754
PMCID: PMC7920495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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