Article

Prospective evaluation of structure-based simulations reveal their ability to predict the impact of kinase mutations on inhibitor binding

2024-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Small molecule kinase inhibitors are critical in the modern treatment of cancers, evidenced by the existence of over 80 FDA-approved small-molecule kinase inhibitors. Unfortunately, intrinsic or acquired resistance, often causing therapy discontinuation, is frequently caused by mutations in the kinase therapeutic target. The advent of clinical tumor sequencing has opened additional opportunities...

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Literature Corpus work: b57fd83d-9278-53b1-a6a7-b41b212ef138
DOI: 10.1101/2024.11.15.623861

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