Article

Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations

2017-12-23

Abstract excerpt

The therapeutic effect of targeted kinase inhibitors can be significantly reduced by intrinsic or acquired resistance mutations that modulate the affinity of the drug for the kinase. In cancer, the majority of missense mutations are rare, making it difficult to predict their impact on inhibitor affinity. This complicates the practice of precision medicine, pairing of patients with clinical trials, and development...

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Literature Corpus work: d709cce0-eb05-564f-95e4-89a30a8e80fc
DOI: 10.1101/239012

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