Article

Single-cell analysis reveals endothelial cell heterogeneity in colorectal cancer: Tip cells drive enhanced angiogenesis and reduced antigen presentation

2023-08-31

Abstract excerpt

This study aims to uncover the heterogeneity of endothelial cells (ECs) in colorectal cancer (CRC) and their crucial role in angiogenesis, with a special focus on tip cells. Using single-cell RNA sequencing to profile ECs, our data suggests that CRC ECs predominantly exhibit enhanced angiogenesis and decreased antigen presentation, a shift in phenotype largely steered by tip cells. We also observed that an increas...

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Literature Corpus work: cfa6ce4c-32bf-5a6b-be66-433654354c3f
DOI: 10.21203/rs.3.rs-3305510/v1

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