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Pan-cancer integrative analyses dissect the remodeling of endothelial cells in human cancers

10 Jul 2024

Abstract excerpt

ABSTRACT Therapeutics targeting tumor endothelial cells (TECs) have been explored for decades, with only suboptimal efficacy achieved, partly due to an insufficient understanding of the TEC heterogeneity across cancer patients. We integrated single-cell RNA-seq data of 575 cancer patients from 19 solid tumor types, comprehensively charting the TEC phenotypic diversities. Our analyses uncovered underappreciated...

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PMID: 39345334
DOI: 10.1093/nsr/nwae231

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