Article

An Altered Glycome Shapes IgA B-Cell Responses and Gut Immunity During Intestinal Inflammation

2026-06-10

Abstract excerpt

A healthy gut immune system balances pathogen defense and tolerance to beneficial microbes. This equilibrium is sustained by coordinated mechanisms where B cells (BCs) play a central role, and secretory immunoglobulin A (SIgA) regulates microbiome composition. In ulcerative colitis (UC), impaired tolerogenic pathways result in exaggerated immune activation, epithelial dysfunction, and tissue damage; however, the c...

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Literature Corpus work: cf9bc035-e560-503a-b8d5-cbe7a662662e
DOI: 10.64898/2026.06.08.730456

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