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Article

IgA subclasses have different effector functions associated with distinct glycosylation profiles

8 Jan 2020

Abstract excerpt

Monomeric serum immunoglobulin A (IgA) can contribute to the development of various autoimmune diseases, but the regulation of serum IgA effector functions is not well defined. Here, we show that the two IgA subclasses (IgA1 and IgA2) differ in their effect on immune cells due to distinct binding and signaling properties. Whereas IgA2 acts pro-inflammatory on neutrophils and macrophages, IgA1 does not have...

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PMID: 31913287
DOI: 10.1038/s41467-019-13992-8

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