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Article

Epithelial glycosylation in gut homeostasis and inflammation.

Nature immunology - 19 Oct 2016

Goto Yoshiyuki, Uematsu Satoshi, Kiyono Hiroshi

Abstract excerpt

Intestinal epithelial cells apically express glycans, especially α1,2-fucosyl linkages, which work as a biological interface for the host-microbe interaction. Emerging studies have shown that epithelial α1,2-fucosylation is regulated by microbes and by group 3 innate lymphoid cells (ILC3s). Dysregulation of the gene (FUT2) encoding fucosyltransferase 2, an enzyme governing epithelial α1,2-fucosylation, is...

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Source

Identifiers

PMID: 27760104
DOI: 10.1038/ni.3587

Genes

FUT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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