Article

IgA displays site- and subclass-specific glycoform differences despite equal glycoenzyme expression

2024-12-16

Abstract excerpt

<h4>Background</h4> Glycosylation is an important posttranslational modification of proteins and in most cases indispensable for proper protein function. Like most soluble proteins, IgA, the second most prevalent antibody in human serum, contains several N- and O-glycosylation sites. While for IgG the impact of Fc glycosylation on effector functions and inflammatory potential has been intensively studied, only li...

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Literature Corpus work: 49d8a5b8-d9a4-5390-9c44-c1bb1551e627
DOI: 10.1101/2024.12.11.627887

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