Article

A drug repurposing screen identifies altiratinib as a selective inhibitor of a key regulatory splicing kinase and a potential therapeutic for toxoplasmosis and malaria

2021-11-03

Abstract excerpt

<h4>Introductory paragraph</h4> The apicomplexa comprise a large phylum of single-celled, obligate intracellular protozoa that infect humans and animals and cause severe parasitic diseases. Available therapeutics against these devastating diseases are limited by suboptimal efficacy and frequent side effects, as well as the emergence and spread of resistance. Here, we use a drug repurposing strategy and identify a...

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Literature Corpus work: cf89fb9e-9cd5-5826-918e-12e01e319915
DOI: 10.1101/2021.11.03.467097

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