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An overview of cdc2‐like kinase 1 (Clk1) inhibitors and their therapeutic indications

19 Oct 2022

Abstract excerpt

Over the past decade, Clk1 has been identified as a promising target for the treatment of various diseases, in which deregulated alternative splicing plays a role. First small molecules targeting Clk1 are in clinical trials for the treatment of solid cancer, where variants of oncogenic proteins derived from alternative splicing promote tumor progression. Since many infectious pathogens hi-jack the host cell's...

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PMID: 36262046
DOI: 10.1002/med.21928

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