Article

Highly accurate protein structure prediction-based virtual docking pipeline accelerating the identification of anti-schistosomal compounds

2025-06-11

Abstract excerpt

Schistosomiasis is a major neglected tropical disease that lacks an effective vaccine and faces increasing challenges from praziquantel resistance, underscoring the urgent need for novel therapeutics. Target-based drug discovery (TBDD) is a powerful strategy for drug development. In this study, we utilized AlphaFold to predict the structures of target proteins from Schistosoma mansoni and Schistosoma japonicum ,...

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Literature Corpus work: aa810bce-5098-5897-b995-6b83be40783b
DOI: 10.1101/2025.06.09.658570

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