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Inhibition of <i>Pf</i> CLK3 a master regulator of malaria parasite RNA-splicing provides the basis for a radical cure for malaria

2025-10-07

Abstract excerpt

Emerging resistance to front-line anti-malarials means there is a race to discover new drugs with novel mechanisms of action that remain effective across multiple stages of the parasite life cycle. Previously we reported the malaria protein kinase, Pf CLK3, as a target offering a cure, prophylaxis and transmission blocking. The homology between Pf CLK3 and human kinases suggested that the mechanism of parasitici...

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Identifiers and source

Literature Corpus work
29668168-cc90-5ff8-95ca-ff914f42a8f2
DOI
10.1101/2025.10.07.680601
Open publication

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Inhibition of <i>Pf</i> CLK3 a master regulator of malaria parasite RNA-splicing provides the basis for a radical cure for malariaDOI 10.1101/2025.10.07.680601
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