Article
Transcriptional control of the TNF gene.
Current directions in autoimmunity - 1 Jan 2010
Falvo James V, Tsytsykova Alla V, Goldfeld Anne E
Abstract excerpt
The cytokine TNF is a critical mediator of immune and inflammatory responses. The TNF gene is an immediate early gene, rapidly transcribed in a variety of cell types following exposure to a broad range of pathogens and signals of inflammation and stress. Regulation of TNF gene expression at the transcriptional level is cell type- and stimulus-specific, involving the recruitment of distinct sets of transcription...
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