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Article

Transcriptional Regulation of the Human Toll-Like Receptor 2 Gene in Monocytes and Macrophages

1 Jun 2002

Abstract excerpt

This report investigates the molecular basis for tissue-restricted and regulated expression of the pattern recognition receptor Toll-like receptor (TLR)2 in human monocytes and macrophages. To define the proximal promoter, the full 5'-sequence and transcriptional start sites of TLR2 mRNA were determined. The human TLR2 gene was found to consist of two 5' noncoding exons followed by a third coding exon....

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PMID: 12023360
DOI: 10.4049/jimmunol.168.11.5629

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