Article
Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1991
Drouet C, Shakhov A N, Jongeneel C V
Abstract excerpt
In macrophages, the TNF-alpha promoter is specifically induced by bacterial endotoxin, and provides a good model for gene regulation during bacterial infections. We have analyzed the protein-binding characteristics and enhancer activity of four kappa B-like enhancers and of a MHC class II-like Y box found in the mouse TNF-alpha promoter. In addition to members of the NF-kappa B/rel transcription factor family, at...
Topics
- Animals
- Base Sequence
- Enhancer Elements, Genetic
- Granulocyte Colony-Stimulating Factor
- Lipopolysaccharides
- Macrophages
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- NF-kappa B