Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Similarities and Differences Between Human and Murine TNF Promoters in Their Response to Lipopolysaccharide

1 Apr 1999

Abstract excerpt

Transcription of the TNF gene is rapidly and transiently induced by LPS in cells of monocyte/macrophage lineage. Previous data suggested that multiple NF-kappaB/Rel binding sites play a role in the transcriptional response to LPS of the murine gene. However, the relevance of homologous sites in the human TNF gene remained a matter of controversy, partly because the high affinity NF-kappaB/Rel site located at -510...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immune Response and Inflammation
Share to NF-κB Signaling Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10201927
DOI: 10.4049/jimmunol.162.7.4045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Similarities and Differences Between Human and Murine TNF Promoters in Their Response to LipopolysaccharidePMID 10201927Read ↗

Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages.Semantic proximity Read ↗

Transcriptional control of the TNF gene.Semantic proximity Read ↗

Lipopolysaccharide-induced tumor necrosis factor-alpha promoter activity is inhibitor of nuclear factor-kappaB kinase-dependent.Semantic proximity Read ↗

Enhancers that regulate <i>TNF</i> gene transcription in human macrophages in response to TLR3 stimulationSemantic proximity Read ↗

Complex NF-κB Interactions at the Distal Tumor Necrosis Factor Promoter Region in Human MonocytesSemantic proximity Read ↗

Two structurally distinct kappa B sequence motifs cooperatively control LPS-induced KC gene transcription in mouse macrophagesSemantic proximity Read ↗

Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites.Semantic proximity Read ↗

Allele-specific chromatin remodeling of the tumor necrosis factor-alpha promoter.Semantic proximity Read ↗

Tumor necrosis factor-alpha- or lipopolysaccharide-induced expression of the murine P-selectin gene in endothelial cells involves novel kappaB sites and a variant activating transcription factor/cAMP response element.Semantic proximity Read ↗

Functional Consequences of a Polymorphism Affecting NF-κB p50-p50 Binding to the <i>TNF</i> Promoter RegionSemantic proximity Read ↗

A Promoter Recruitment Mechanism for Tumor Necrosis Factor-α-induced Interleukin-8 Transcription in Type II Pulmonary Epithelial CellsSemantic proximity Read ↗

Regulation of the Tissue Factor Gene in Human Monocytic CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.