Article

YAP1 Contributes to The Development of Contractile Force and Sarcomere Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes

2024-07-05

Abstract excerpt

<h4>Background</h4> Perspective regenerative therapies for injured myocardium focus on reactivating developmental processes to regenerate damaged contractile tissue. In animal models, the Hippo pathway was shown to improve heart regeneration after myocardial infarction, possibly by expanding the pool of cardiomyocytes. We hypothesized that activating the Hippo pathway’s downstream effector, Yes Associated Protein...

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Literature Corpus work: cf7e2ba1-0752-577f-ad17-dfada7860414
DOI: 10.1101/2024.07.02.601803

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