Article

Cardiac fibroblast anisotropy is determined by YAP-dependent cellular contractility and ECM production

2024-12-17

Abstract excerpt

<h4>ABSTRACT</h4> Cardiac fibroblasts (CFbs) determine the topological arrangement and the anisotropy of the heart tissue - essential features for maintaining tissue integrity and function - through the production and remodeling of the extracellular matrix (ECM). Under pathological conditions, CFbs can activate into myofibroblasts and promote maladaptive ECM remodeling that may lead to heart failure. Yes-Associat...

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Literature Corpus work: 331a2b61-f525-599c-9fd7-46e139afe435
DOI: 10.1101/2024.12.14.628335

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