Article

YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

2024-06-03

Abstract excerpt

Hypertrophy Cardiomyopathy (HCM) is the most prevalent hereditary cardiovascular disease – affecting >1:500 individuals. Advanced forms of HCM clinically present with hypercontractility, hypertrophy and fibrosis. Several single-point mutations in b-myosin heavy chain (MYH7) have been associated with HCM and increased contractility at the organ level. Different MYH7 mutations have resulted in increased, decreased,...

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Literature Corpus work: 003073aa-2598-559a-9324-983763e4b1dd
DOI: 10.1101/2024.06.03.597045

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