Article

Endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

2017-09-11

Abstract excerpt

Patients who have had their primary pancreatic ductal adenocarcinoma (PDA) surgically resected often develop metastatic disease, exemplifying the problem of latent metastases. Livers from patients and mice with PDA contained single, disseminated cancer cells (DCCs) with an unusual phenotype of being cytokeratin-19 (CK19) - and MHC class I (MHCI) - . We created a mouse model to determine how DCCs develop, their r...

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Literature Corpus work: cf68499d-da8e-50a8-b7cc-bf9d09dac67a
DOI: 10.1101/187484

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