Article

Langerhans islets induce anti-tumor immunity at the expense of glycemic control and predict chemotherapy response in pancreatic cancer

2021-03-15

Abstract excerpt

<h4>ABSTRACT</h4> Induction of anti-tumor immunity in pancreatic ductal adenocarcinoma (PDA) is an unresolved challenge. Systematic investigation of the microenvironment of primary pancreatic tumors revealed a role of endocrine Langerhans islets in the coordination of immune activation. We found that intratumoral β-cells, regulated via STAT3, secrete C-C motif chemokine ligand 27 (CCL27) and thereby promote a T...

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Literature Corpus work: eec28fd8-2e08-51f9-9610-0d57f069f84d
DOI: 10.1101/2021.03.13.435100

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