Article

Tissue-specific tolerance mechanisms and lymph node co-drainage converge to shape T cell immunity in the upper digestive system and regulate pancreatic cancer progression

2025-12-05

Abstract excerpt

<h4>Summary</h4> The liver, pancreas, and duodenum share lymph nodes (LNs), providing a unique system to examine how tissue origin of self-antigens shapes T cell fate. Comparing mice expressing ovalbumin (OVA) from distinct subcellular compartments, we found that cytosolic OVA from liver or pancreas, but not gut, was immunologically ignored. High-dose hepatic secreted OVA triggered antigen-specific T cell deletio...

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Literature Corpus work: 64bad4f3-1f77-5c2a-8b6a-ca97b46773c0
DOI: 10.64898/2025.12.02.691870

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