Article

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6

2024-12-30

Abstract excerpt

The COVID-19 pandemic has been driven by SARS-CoV-2 variants with enhanced transmission and immune escape. Apart from extensive evolution in the Spike protein, non-Spike mutations are accumulating across the entire viral genome and their functional impact is not well understood. To address the contribution of these mutations, we reconstructed genomes of recent Omicron variants with disabled Spike expression (repli...

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Literature Corpus work: 46fe290b-32ca-5cfc-bfa6-c625d4d7fd2a
DOI: 10.1101/2024.12.30.628795

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