Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

doi:10.1371/journal.ppat.1013020

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Article

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

PLoS pathogens - 1 Mar 2025

Taha Taha Y, Ezzatpour Shahrzad, Hayashi Jennifer M, Ye Chengjin, Zapatero-Belinchón Francisco J, Rosecrans Julia A, Kimmerly Gabriella R, Chen Irene P, Walcott Keith, Kurianowicz Anna, Jorgens Danielle M, Chaplin Natalie R, Choi Annette, Buchholz David W, Sahler Julie, Hilt Zachary T, Imbiakha Brian, Vagi-Szmola Cecilia, Montano Mauricio, Stevenson Erica, Gordon Martin, Swaney Danielle L, Krogan Nevan J, Whittaker Gary R, Martinez-Sobrido Luis, Aguilar Hector C, Ott Melanie

Abstract excerpt

The COVID-19 pandemic has been driven by SARS-CoV-2 variants with enhanced transmission and immune escape. Apart from extensive evolution in the Spike protein, non-Spike mutations are accumulating across the entire viral genome and their functional impact is not well understood. To address the contribution of these mutations, we reconstructed genomes of recent Omicron variants with disabled Spike expression...

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Identifiers

PMID: 40163530
DOI: 10.1371/journal.ppat.1013020
PMCID: PMC11981139

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