Article

CSF α-synuclein seed amplification kinetic profiles are associated with cognitive decline in PD

2023-07-26

Abstract excerpt

<title>Abstract</title> <p>Seed amplification assays have been implemented in Parkinson’s disease to reveal disease-specific misfolded alpha-synuclein aggregates in biospecimens. While the assays’ qualitative dichotomous seeding response is valuable to stratify and enrich cohorts for alpha-synuclein pathology in general, more quantitative parameters that are associated with clinical dynamics of disease progressio...

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Literature Corpus work: cf3d3d20-3d38-5093-95ce-7aeeea777249
DOI: 10.21203/rs.3.rs-3178181/v1

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