Article

Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein

2023-01-22

Abstract excerpt

<h4>SUMMARY</h4> Double homeobox (DUX) genes are unique to eutherian mammals and normally expressed transiently during zygotic genome activation. The canonical member, DUX4, is involved in facioscapulohumeral muscular dystrophy (FSHD) and cancer, when misexpressed in other contexts. We evaluate the 3 human DUX genes and the ancestral single homeobox gene sDUX from the non-eutherian mammal, platypus, and find that...

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Literature Corpus work: d2ae26d4-2f9c-52de-9b06-8797e0c2750b
DOI: 10.1101/2023.01.21.524976

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