Article

Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution

2023-06-06

Abstract excerpt

Structural genomics consortia established that protein crystallization is the primary obstacle to structure determination using x-ray crystallography. We previously demonstrated that crystallization propensity is systematically related to primary sequence, and we subsequently performed computational analyses showing that arginine is the most overrepresented amino acid in crystal-packing interfaces in the Protein D...

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Literature Corpus work: cf32c5d3-7121-5ac2-983e-8ae37edadaec
DOI: 10.1101/2023.06.03.543563

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