Salvage or recovery of failed targets by mutagenesis to reduce surface entropy.

Abstract excerpt

The success of macromolecular crystallization depends on the protein's ability to form specific, cohesive intermolecular interactions that serve as crystal contacts. In the cases where the protein lacks surface patches conducive to such interactions, crystallization may not occur. However, it is possible to enhance the likelihood of crystallization by engineering such patches through site-directed mutagenesis,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amino Acids
• Share to Crystallization
• Share to Crystallography, X-Ray