Article
The "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Derewenda Zygmunt S, Godzik Adam
Abstract excerpt
Crystallization of macromolecules has long been perceived as a stochastic process, which cannot be predicted or controlled. This is consistent with another popular notion that the interactions of molecules within the crystal, i.e., crystal contacts, are essentially random and devoid of specific physicochemical features. In contrast, functionally relevant surfaces, such as oligomerization interfaces and specific...
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