Article

Tumor Suppressor SMAR1 Regulates PKM Alternative Splicing by HDAC6 Mediated Deacetylation of PTBP1

2021-02-01

Abstract excerpt

<title>Abstract</title> <p>Background:Highly proliferating cancer cells exhibit the Warburg effect by regulation of <italic>PKM</italic> alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in the nuclear matrix where various MARBPs actively participate in the alternative splicing events. SMAR1, being a MARBP and an important tumor suppressor, i...

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Literature Corpus work: cf22751f-ca6e-590a-b39c-7fb32a738b08
DOI: 10.21203/rs.3.rs-151525/v1

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