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Genomic analysis reveals HDAC1 regulates clinically relevant transcriptional programs in pancreatic cancer

2022-09-06

Abstract excerpt

<h4>ABSTRACT</h4> Novel strategies are needed to combat multidrug resistance in pancreatic ductal adenocarcinoma (PDAC). We applied genomic approaches to understand mechanisms of resistance in order to better inform treatment and precision medicine. Altered function of chromatin remodeling complexes contribute to chemoresistance. Our study generates and analyzes genomic and biochemical data from PDAC cells overex...

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Literature Corpus work
ae0dfc72-b003-553d-8a4f-8cd4ed1ed213
DOI
10.1101/2022.09.06.506214
Open publication

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Genomic analysis reveals HDAC1 regulates clinically relevant transcriptional programs in pancreatic cancerDOI 10.1101/2022.09.06.506214
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