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TGF-β-induced MIR99AHG synergizes with PTBP1 to trigger a splicing switch of SMARCA1 that promotes invadopodia formation for metastasis in colorectal cancer

2022-12-20

Abstract excerpt

<title>Abstract</title> <p> Alternative splicing (AS) of pre-mRNAs is an essential process that regulates gene expression and functional diversity, yet the underlying regulatory mechanisms that control this process during cancer metastasis are not clear. Here, we uncovered that a long non-coding RNA (lncRNA), MIR99AHG, mediates regulation of AS to alter chromatin remodeler function and promote invadopodia format...

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Literature Corpus work
41c8acfe-d14a-513d-960f-5d435d6df1bf
DOI
10.21203/rs.3.rs-1538014/v2
Open publication

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TGF-β-induced MIR99AHG synergizes with PTBP1 to trigger a splicing switch of SMARCA1 that promotes invadopodia formation for metastasis in colorectal cancerDOI 10.21203/rs.3.rs-1538014/v2
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