Article

Polygenic risk scores and Parkinson’s disease in South Africa: Moving towards ancestry-informed disease prediction

2025-09-30

Abstract excerpt

Parkinson’s disease (PD) is a complex neurodegenerative disorder with environmental and genetic influences. Using genotyping array data of 661 South African PD cases and 737 controls, a polygenic risk score (PRS) analysis was conducted using PRSice-2. Summary statistics were used from two PD association studies as base datasets. The target dataset was split into training (70%; n=979) and validation (30%; n=419) co...

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Literature Corpus work: cf0d5521-b814-5a1e-a235-99df364db58b
DOI: 10.1101/2025.09.29.25336747

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